According to OPTA statistics, in the past 9 games between Premier League teams and La Liga teams in the Champions League, the Premier League teams have won 8 games. Only Barcelona defeated Newcastle 2-0 in the first round of the UEFA Champions League in September this year and won a game for La Liga.
Premier League vs. La Liga in the past 9 rounds of the Champions League
Chelsea 3-0 Barcelona
Newcastle 2-0 Biba
Liverpool 1-0 Real Madrid
Manchester City 2-0 Villarreal Erl
Arsenal 4-0 Atletico
Barcelona 2-1 Newcastle
Liverpool 3-2 Atletico
Tottenham 1-0 Villarreal
Arsenal 2-0 Bilbao